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KMID : 0878220170290040347
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Journal of Sasang Constitutional Medicine
2017 Volume.29 No. 4 p.347 ~ p.368
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Anti-atopic Effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) in DNCB-induced Atopic Dermatitis-like Skin Lesions NC/Nga Mice
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Kwak Jin-Young
Choi Hee-Jeong
Park Jung-Mi
Park Jung-Hwan
Kho Young-Mee
Jang Tae-Soo
Ahn Taek-Won
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Abstract
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The aim of this study is to investigate the effect of Zizyphus jujuba var. spinosa Composite oil(ZjJ-C_oil) and Aralia cordata var. continentalis Composite oil(ARC-C_oil) to NC/Nga mice induced in Atopic dermatitis-like skin lesions by DNCB.
NC/Nga mice which have been induced to Atopic dermatitis-like skin lesions by DNCB are divided into 4 groups, the first is the mice which have been spread with izyphus jujuba var. spinosa Composite oil(ZjJ-C_oil), the second is the mice which have been spread with Aralia cordata var. continentalis Composite oil(ARC-C_oil), the third is which have been spread with dexamethasone (Dexa.) 0.5% on their Atopic lesion, the last is the control group. Then We analyzed skin clinical score, blood sample of each group of measure state of the dorsal skin, the number of immunocytes, and resect the skin lesion to anlayze the state of cells.
There are meaningful results of measuring the number of IgE, IL-4, IL-13, IFN-γ, IL-5, the total cells in ALN, dorsal skin, CD4+ Th, CD11b+/Gr-1+ in PBMCs, CD4+ Th, B220+/CD23+ in ALN, CD4+, CD8+ Th in dorsal skin, the level of COX-2, TNF-α, TGF-β1, IL-4, IL-13 mRNA, the state of the skin lesion and cells in the group with ZjJ-C_oil, ARC-C_oil cream in comprarison with the control group.
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KEYWORD
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Atopic Dermatitis, NC/Nga Mouse, izyphus jujuba var. spinosa Composite oil(ZjJ-C_oil), Aralia cordata var. continentalis Composite oil(ARC-C_oil)
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